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Prostacyclin analogs reverse excessive mitochondrial fission and cell proliferation phenotypes by inhibiting phosphorylation of the mitochondrial fission protein DRP1, revealing the impact of dynamic balance on immune-metabolic crosstalk ( mtDNA released from mitochondrial damage acts as a danger signal, which can activate the NLRP3 inflammasome, promote caspase-1-mediated cleavage of IL-1/IL-18 and macrophage recruitment

It is not approved by Health Canada, the FDA, or any other regulatory authority for human or veterinary use

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