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Interestingly, in the mid-19th century valerian was considered a stimulant that caused some of the same complaints it was thought to treat and, therefore, was not considered a useful medicinal herb

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acetyl-LC) can promote characteristics of mitochondrial biogenesis, such as increased mitochondrial DNA and AMPK activity, and increased PGC1 , NRF-1 or mitochondrial transcription factor A protein levels, to counteract these mitochondrial dysfunctions (Reference Montesano, Senesi and Vacante72Reference Hota, Hota and Chaurasia77)

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