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By targeting multiple mechanismssuch as enhancing insulin secretion, suppressing glucagon release, slowing gastric emptying, and promoting satietyGLP-1 RAs provide significant improvements in glycemic control, weight reduction, and long-term cardiovascular and renal health (6)(16)(23)

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Heterogeneity of mortality effects across studies was noted, reflecting differences in glycemic targets, therapeutic approaches, and, importantly, population characteristics

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