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Optogenetic stimulation of PVH-projecting GABA LH neurons increases inhibitory post-synaptic current (IPSC) in PVH neurons, leading to increased feeding, while disruption of GABA receptors in the PVH reduced feeding [89]

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Compounded semaglutide from FDA-registered 503B outsourcing facilities costs $149$399 monthly depending on dose strength and provider markup structure