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Andrew Lee, clinical spokesperson for the American Academy of Ophthalmology and a neuro-ophthalmologist at Houston Methodist Hospital, said he's had some patients who developed NAION who were taking semaglutide, but the question was always whether this is a causal association or merely an association alone. People with Type 2 diabetes are already at an increased risk for vision problems, including NAION

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For more on managing nausea, GI distress, and the rest, see the dedicated guide on semaglutide side effect management in 2026

PlexusDx's Precision Peptide Genetic Test analyzes your GLP1R rs6923761 and GIPR rs1800437 variants, which influence how quickly and intensely your body responds to semaglutide