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With tirzepatide, your body reduces appetite and improves insulin sensitivity

One study of adults with severe obesity showed an average weight loss of 22.6%, or 55.8 pounds, after 80 weeks, while another study of adults with obesity and diabetes showed participants lost an average of 20.8% of their weight, or about 49.6 pounds

Medications such as retatrutide, which affect multiple hormone pathways, GLP-1, GIP, and glucagon, could potentially provide quicker or more dramatic effects than single-pathway counterparts

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