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Estimated treatment differences between cohorts showed the semaglutide 2.4 mg cohort had significantly greater percentage ( 15.0%) and absolute reduction in weight ( 15.7 kg), greater reduction in BMI ( 4.2 kg/m 2 ), and significantly greater improvements in cardiometabolic risk factors, including SBP ( 6.7 mmHg), DBP ( 2.7 mmHg), HbA1c ( 0.5%), HDL-C (1.2 mg/dl), LDL-C ( 10.4 mg/dl), and triglycerides ( 34.3 mg/dl) at 12 months

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