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It can have severe effects upon the dogs' respiratory system function, especially as an added risk factor for breathing difficulties due to brachycephalic airway obstruction syndrome (BAOS), another disorder to which cavaliers are pre-disposed due to their shortened muzzle lengths

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Additionally, Verapamil has been shown to reduce bacterial persistence, a major challenge in TB treatment, by enhancing drug accumulation and immune-mediated clearance [84]

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