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This neural communication eventually excites the preganglionic motor neurons of the DMV, which subsequently activate postganglionic cholinergic neurons, leading to enhanced GI motility (70, 71)

(ii) Cu 2+ induces the secretion of acidic SMase from leukocytes which in turn leads to accumulation of erythrocytic ceramide [131] and (iii) treatment of erythrocytes with extracellular SMase resulted in ceramide-associated alterations in membrane-cytoskeleton interactions and membrane organization [125]

The peptide is applied to the scalp surface and designed to penetrate locally rather than enter systemic circulation in significant amounts

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