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L-arginine is a non-essential amino acid that has several important metabolic and biological effects on the body

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Methanolic leaf extracts of Hawaiian kava cultivars showed stronger binding inhibition to several CNS receptorsincluding GABA A , dopamine D2, opioid (, ), and histamine (H1, H2)than root extracts, suggesting that compounds beyond the main kavalactones may contribute to the pharmacological effects of kava leaves

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