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2 The FDA approval of Wegovy HD is based on the results of the STEP UP trial program, which included STEP UP, a 72-week study which evaluated the efficacy and safety of once-weekly Wegovy 7.2 mg compared to placebo and Wegovy 2.4 mg, as an adjunct to lifestyle intervention in 1,407 adults with obesity (BMI 30 kg/m 2 or greater), without diabetes

One further nuance worth noting: the addition of GIP in both tirzepatide and retatrutide is hypothesised to improve gastrointestinal tolerability relative to GLP-1 alone at comparable efficacy

The post frames these as typical patterns rather than promises, noting that adherence, diet quality, exercise, and individual metabolic factors influence actual results, and that not all patients reach maximum weight loss

Some peptides and amino acids trigger the release of GLP-1 in the intestines