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Adult neurogenesis is severely affected in PD, although the exact mechanisms and effects of these changes are not fully understood, there may be a dynamic interaction between them and PD-related pathology

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It is becoming increasingly clear that, by looking at single cells types separately or isolated islets, deprived of the natural microcirculation, one misses important paracrine effects that each hormone and cell type exert on its surrounding cells, because all substances reach the peripheral cells by uncontrolled diffusion