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For patients that desire it, a topical anesthetic can be used

or intestinal routes

The peptide crosses the blood-brain barrier to some extent, which is important for a compound intended to affect central nervous system function

Tumor cells change their characteristics throughout the process, which enable them to proliferate and migrate, invade surrounding tissue, intravasate through the basement membrane into blood or lymphatic vessels, survive during circulation through the blood or lymphatic system, stay at distant sites, extravasate into a new environment tissue, and proliferate by inducing angiogenesis [10,11,12]