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In summary, compounds 47 , 55 , 72 , and 74 resemble allopurinol and febuxostat, as they are multiorgan targets and hepatotoxic, whereas compounds 65 and 83 resemble topiroxostat, displaying a milder toxicity profile (see the Supporting Information: File S1)

418,443,459 HGF also affects intracellular redox balance, which is crucial for liver regeneration

Accessed at ncbi.nlm.nih.gov/books/NBK547925 on April 22, 2024