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Urgent medical assessment should be sought for severe, persistent abdominal pain, vomiting, inability to pass stool or gas (possible obstruction), or symptoms suggesting pancreatitis or gallbladder disease

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The interpretation of these transcriptomic findings has been a continuing area of discussion, with some researchers viewing the broad effects as evidence of a regulatory function and others viewing them with caution given the difficulty of distinguishing direct effects from secondary consequences in such broad gene-expression landscapes